Article

Prognostic Significance of Bile Acid Metabolism in Colorectal Cancer: An Integrative Multi-Omics, Single-Cell, and Spatial Analysis

2026-03-12

Abstract excerpt

<title>Abstract</title> <p> Metabolic reprogramming is a hallmark of colorectal cancer (CRC), yet the prognostic role of the bile acid metabolism pathway, regulated by host genetics and gut microbiota, remains poorly understood. We utilized an integrative multi-omics framework, combining bulk transcriptomics, single-cell, and spatial transcriptomics with microbiome data, to systematically dissect the prognostic...

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Literature Corpus work: ae8c1f0a-c398-59ce-a40b-3ec7120bbbb5
DOI: 10.21203/rs.3.rs-8062501/v1

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