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Article

Cancer-associated fibroblasts drive metabolic heterogeneity in colorectal cancer cells: predictions from metabolic modeling.

NPJ systems biology and applications - 4 Mar 2026

Elton Elizabeth, Tavakoli Niki, Cetin Handan, Finley Stacey D

Abstract excerpt

KRAS-mutant colorectal cancer (CRC) undergoes metabolic reprogramming that promotes tumor progression and drug resistance. Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play a pivotal role in modulating these metabolic adaptations in CRC. This study applies flux sampling combined with representation learning and hierarchical clustering to a computational model of...

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Identifiers

PMID: 41781387
DOI: 10.1038/s41540-026-00673-8
PMCID: PMC13077082

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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