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Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer

15 May 2025

Abstract excerpt

Metabolic reprogramming is a defining feature of pancreatic cancer, influencing tumor progression and the tumor microenvironment. By integrating single-cell transcriptomics, spatial transcriptomics, and spatial metabolomics, this study visualized the spatial co-localization of metabolites and gene expression within tumor samples, uncovering metabolic heterogeneity and intercellular interactions. Spatial...

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PMID: 40538442
DOI: 10.1016/j.isci.2025.112681

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