Article

Soma-seq links intracellular protein states to transcriptional programs in the human brain

2026-05-29

Abstract excerpt

Neurodegenerative disease is largely driven by pathological protein states, which cannot be fully inferred from transcript levels. Yet, joint measurement of cytoplasmic proteins and RNA in single cells from archival human brain tissue remains challenging. Here we present Soma-seq, a method integrating transcriptome and antibody-based intracellular protein measurements in single cells from frozen human brain tissue...

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Literature Corpus work: 02cf02df-1893-5042-9685-418d92dcb794
DOI: 10.64898/2026.05.28.728561

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