Article

Joint single-cell measurements of surface proteins, intracellular proteins and gene expression with icCITE-seq

2025-01-14

Abstract excerpt

The development of single-cell RNA-sequencing assays has transformed our understanding of cellular and tissue heterogeneity, yielding significant insights into disease biology and its underlying mechanisms. In this work, we describe icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e38ec2b-a01c-507d-ba1d-eb0b9745757d
DOI: 10.1101/2025.01.11.632564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Joint single-cell measurements of surface proteins, intracellular proteins and gene expression with icCITE-seqDOI 10.1101/2025.01.11.632564Read

Single-cell Analysis of Intracellular Transport and Expression of Cell Surface ProteinsSemantic proximity Read

InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory MechanismsSemantic proximity Read

Subcellular transcriptome sequencing with single cell APEX-seq identifies regulators of cell-cell interactionsSemantic proximity Read

InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory MechanismsSemantic proximity Read

Genular: An Integrated Platform for Defining Cellular Identity and Function through Single-Cell Gene Expression and Multi-Domain Biological DataSemantic proximity Read

TEA-seq: a trimodal assay for integrated single cell measurement of transcription, epitopes, and chromatin accessibilitySemantic proximity Read

Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissuesSemantic proximity Read

Integration of Transcriptome and Cell Surface Protein Expression by LinQ-View Identifies Unique Immune SubpopulationsSemantic proximity Read

ImmunoPheno: A Computational Framework for Data-Driven Design and Analysis of Immunophenotyping ExperimentsSemantic proximity Read

Protein-based cell population discovery and annotation for CITE-seq data identifies cellular phenotypes associated with critical COVID-19 severitySemantic proximity Read

Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunctionSemantic proximity Read

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clustersSemantic proximity Read