Article

Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics

2025-10-06

Abstract excerpt

Increase in the occurrence of human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI adapting to become human transmissible. Studies identified hemagglutinin (HA) acid stability and receptor preference as essential traits that shape host tropism. Mutations that increase HA stability and affinity for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02ccc93b-bc75-5d27-a8c8-777eeee023fe
DOI: 10.1101/2025.10.06.680362

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation DynamicsDOI 10.1101/2025.10.06.680362Read

Characterizing receptor flexibility to predict mutations that lead to human adaptation of influenza hemagglutininSemantic proximity Read

Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus.Semantic proximity Read

Characterizing Receptor Flexibility to Predict Mutations That Lead to Human Adaptation of Influenza Hemagglutinin.Semantic proximity Read

An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level.Semantic proximity Read

N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammalsSemantic proximity Read

Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein.Semantic proximity Read

A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.Semantic proximity Read

What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor?Semantic proximity Read

Cell Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Ferret Airborne TransmissionSemantic proximity Read

Cell-Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Airborne Transmission in Ferret Model.Semantic proximity Read

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity.Semantic proximity Read

Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells.Semantic proximity Read