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Article

Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology.

Nucleic acids research - 23 Jun 2023

Rezvykh Alexander P, Ustyugov Aleksey A, Chaprov Kirill D, Teterina Ekaterina V, Nebogatikov Vladimir O, Spasskaya Daria S, Evgen'ev Michael B, Morozov Alexey V, Funikov Sergei Yu

Abstract excerpt

Dysfunction of the RNA-binding protein (RBP) FUS implicated in RNA metabolism can cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Mutations affecting FUS nuclear localization can drive RNA splicing defects and stimulate the formation of non-amyloid inclusions in affected neurons. However, the mechanism by which FUS mutations contribute to the development of ALS remains uncertain....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37115004
DOI: 10.1093/nar/gkad319
PMCID: PMC10287951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology.PMID 37115004Read ↗

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