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PAXX binding to the NHEJ machinery explains functional redundancy with XLF

31 May 2023

Abstract excerpt

Nonhomologous end joining is a critical mechanism that repairs DNA double-strand breaks in human cells. In this work, we address the structural and functional role of the accessory protein PAXX [paralog of x-ray repair cross-complementing protein 4 (XRCC4) and XRCC4-like factor (XLF)] in this mechanism. Here, we report high-resolution cryo-electron microscopy (cryo-EM) and x-ray crystallography structures of the...

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PMID: 37256950
DOI: 10.1126/sciadv.adg2834

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAXX binding to the NHEJ machinery explains functional redundancy with XLFPMID 37256950Read ↗

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repairSemantic proximity Read ↗

Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturationSemantic proximity Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

XRCC4's interaction with XLF is required for coding (but not signal) end joining.Semantic proximity Read ↗

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytesSemantic proximity Read ↗

Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factorsSemantic proximity Read ↗

The spatial organization of non-homologous end joining: From bridging to end joiningSemantic proximity Read ↗

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining.Semantic proximity Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining.Semantic proximity Read ↗

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.Semantic proximity Read ↗

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity PurificationSemantic proximity Read ↗

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