Article

A <i>trans</i> -piRNA network and transcriptional antagonism shape piRNA cluster function

2026-04-09

Abstract excerpt

PIWI-interacting (pi)RNAs protect animal germlines from transposable elements (TEs) by guiding their sequence-specific repression. In Drosophila germline, piRNAs are encoded in distinct genomic regions, piRNA clusters (piCs), that are transcribed by a non-canonical machinery that is anchored on chromatin by the HP1 paralogue Rhino. Studies of transgenic piCs revealed that piRNA biogenesis depends on cytoplasmic i...

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Literature Corpus work: 02757c96-ea0d-541b-bf28-29512b4b9eac
DOI: 10.64898/2026.04.08.717276

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