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Article

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin-associated histone modifications

2020-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Aging has been shown to be a strong driver of DNA methylation changes, leading to the development of robust biomarkers in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages for studying mammalian aging. Additionally, we incorporated behavioral data, unsupervised machine learning,...

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Literature Corpus work
026d4dd7-d263-588f-970c-cf81f248d859
DOI
10.1101/2020.05.13.094292
Open publication

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A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin-associated histone modificationsDOI 10.1101/2020.05.13.094292
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