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Article

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin.

eLife - 12 Nov 2020

Levine Morgan, McDevitt Ross A, Meer Margarita, Perdue Kathy, Di Francesco Andrea, Meade Theresa, Farrell Colin, Thrush Kyra, Wang Meng, Dunn Christopher, Pellegrini Matteo, de Cabo Rafael, Ferrucci Luigi

Abstract excerpt

Robust biomarkers of aging have been developed from DNA methylation in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats-a model with unique physical, physiological, and biochemical advantages-by incorporating behavioral data, unsupervised machine learning, and network analysis to identify epigenetic signals that not only track with age, but also relates to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33179594
DOI: 10.7554/eLife.59201
PMCID: PMC7661040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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