Article
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.
Epigenomics - 1 Jan 2015
Vallianatos Christina N, Iwase Shigeki
Abstract excerpt
Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia....
Topics
- Child Development Disorders, Pervasive
- Developmental Disabilities
- Histone Demethylases
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Intellectual Disability
- Methylation
- Mutation
- Schizophrenia