Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.

Epigenomics - 1 Jan 2015

Vallianatos Christina N, Iwase Shigeki

Abstract excerpt

Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child Development Disorders, Pervasive
Share to Developmental Disabilities
Share to Histone Demethylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Intellectual Disability

Share to Methylation

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 26077434
DOI: 10.2217/epi.15.1
PMCID: PMC4501478

Genes

PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.PMID 26077434Read ↗

Regulation of histone H3K4 methylation in brain development and disease.Semantic proximity Read ↗

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment.Semantic proximity Read ↗

Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.Semantic proximity Read ↗

Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects.Semantic proximity Read ↗

Epigenome and transcriptome changes in <i>KMT2D</i> -related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neuronsSemantic proximity Read ↗

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disordersSemantic proximity Read ↗

A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21ASemantic proximity Read ↗

Epigenetic layers and players underlying neurodevelopment.Semantic proximity Read ↗

Holoprosencephaly in Kabuki syndrome.Semantic proximity Read ↗

Histones: coming of age in Mendelian genetic disorders.Semantic proximity Read ↗

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.Semantic proximity Read ↗

Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.