Back to search

Article

The REST/NRSF pathway as a central mechanism in CNS dysfunction

2015-01-01

Abstract excerpt

Deciphering the complex molecular circuitry of the brain is crucial for understanding how processes such as higher cognitive function and behaviour are disrupted in neurological disease. Thus it is imperative to explore further the regulatory mechanisms centred on key transcription factors that orchestrate such processes including REST/NRSF (restrictive element-1 silencing transcription factor/neuron restrictive s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1ea23f25-fe03-5f6e-b838-29ee959e7901
DOI
10.17638/02014040
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The REST/NRSF pathway as a central mechanism in CNS dysfunctionDOI 10.17638/02014040
NRSF–mediated repression of neuronal genes in developing brain persists in the absence of NRSF-Sin3 interactionSemantic proximity
Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disordersSemantic proximity
Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic StrategiesSemantic proximity
Excitation-Inhibition Imbalance Underlies Perioperative Neurocognitive Disorders: A Single-Nucleus Transcriptomic Perspective in Mice HippocampusSemantic proximity
The interplay between miRNAs and chromatin regulators underpins premature differentiation within neurodevelopmental disorders (NDDs)Semantic proximity
Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE.Semantic proximity
Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.Semantic proximity
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.Semantic proximity
Title Plasma Repressor Element 1-Silencing Transcription Factor Levels Decrease in Patients With Alzheimer's Disease Semantic proximity
Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.Semantic proximity
Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptorSemantic proximity
NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray studySemantic proximity
Select a neighboring publication to make it the new centre.