Article
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma.
Cancer research - 1 Dec 2020
Rusert Jessica M, Juarez Edwin F, Brabetz Sebastian, Jensen James, Garancher Alexandra, Chau Lianne Q, Tacheva-Grigorova Silvia K, Wahab Sameerah, Udaka Yoko T, Finlay Darren, Seker-Cin Huriye, Reardon Brendan, Gröbner Susanne, Serrano Jonathan, Ecker Jonas, Qi Lin, Kogiso Mari, Du Yuchen, Baxter Patricia A, Henderson Jacob J, Berens Michael E, Vuori Kristiina, Milde Till, Cho Yoon-Jae, Li Xiao-Nan, Olson James M, Reyes Iris, Snuderl Matija, Wong Terence C, Dimmock David P, Nahas Shareef A, Malicki Denise, Crawford John R, Levy Michael L, Van Allen Eliezer M, Pfister Stefan M, Tamayo Pablo, Kool Marcel, Mesirov Jill P, Wechsler-Reya Robert J
Abstract excerpt
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterogeneity, most patients with medulloblastoma receive similar therapies, including surgery, radiation, and intensive chemotherapy. Although these treatments prolong survival, many...
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