Article

Pediatric glioblastoma - unlike normal cells - are sensitive to the combination of vorinostat and olaparib and to its downstream effector - phosphorylated eIF2α

2020-11-25

Abstract excerpt

Current therapies offer only a short relief for patients with pediatric glioblastoma (PED-GBM). Therefore, expanding treatment options for this fatal disease is of utmost importance. We found that PED-GBM cell lines, originated from diffuse intrinsic pontine glioma expressing H3K27M mutation (DIPG), or from hemispheric glioma expressing H3G34R mutation, are sensitive to combinations of histone deacetylase and PARP...

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Literature Corpus work: f9dec414-9e46-5c85-849b-bd33fb40f738
DOI: 10.1101/2020.11.25.397497

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