Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition

2 Feb 2018

Abstract excerpt

Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Mechanisms of cancer metastasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29490009
DOI: 10.1093/brain/awy039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitionPMID 29490009Read ↗

Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting StrategiesSemantic proximity Read ↗

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).Semantic proximity Read ↗

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Semantic proximity Read ↗

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscapeSemantic proximity Read ↗

Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.Semantic proximity Read ↗

CK1α agonists attenuate medulloblastoma stemness and relapse riskSemantic proximity Read ↗

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fateSemantic proximity Read ↗

Challenges and Recent Advances in Medulloblastoma TherapySemantic proximity Read ↗

Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.Semantic proximity Read ↗

ENTPD1 (CD39) and NT5E (CD73) expression in human Medulloblastoma: an in silico analysisSemantic proximity Read ↗

Molecular-Genetic and In Silico 3D Characterization of an Adamantinomatous Craniopharyngioma, the ‘Chameleon’ Among Pediatric Brain TumorsSemantic proximity Read ↗

Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges AheadSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.