Article

DNA-Dependent Protein Kinase Inhibitors PI-103 and Samotolisib Augment CRISPR/Cas9 Knockin Efficiency in Human T Cells

2024-10-18

Abstract excerpt

1. The adoptive cell transfer of ex vivo expanded tumor infiltrating lymphocytes (i.e., TIL therapy) is a promising clinical strategy and recently FDA approved for melanoma but has major limitations including that not all tumors are inflamed. Moreover, tumor-specific clones can be rare and in an exhausted state due to the suppressive tumor microenvironment. These obstacles can be overcome by engineering autologou...

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Literature Corpus work: 022d1c93-e5f2-5ef3-aded-7680dddcc7ba
DOI: 10.1101/2024.10.18.618985

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