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Article

Challenges of CRISPR-Based Gene Editing in Primary T Cells

1 Feb 2022

Abstract excerpt

Adaptive T-cell immunotherapy holds great promise for the successful treatment of leukemia, as well as other types of cancers. More recently, it was also shown to be an effective treatment option for chronic virus infections in immunosuppressed patients. Autologous or allogeneic T cells used for immunotherapy are usually genetically modified to express novel T-cell or chimeric antigen receptors. The production of...

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PMID: 35163611
DOI: 10.3390/ijms23031689

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