Back to search

Article

Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy

2020-11-05

Abstract excerpt

Chimeric antigen receptor T (CART) cells are engineered with an artificial receptor which redirects T cells to recognize cancer cells expressing a particular surface antigen. CART cell therapy has been astonishingly successful at eradicating certain B cell malignancies, but relapse is common, and efficacy is lacking in many cancers. Gene editing of CART cells is being investigated to enhance efficacy and safety an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b174fffb-3f3c-5bac-b4de-f9e97a99212d
DOI
10.1182/blood-2020-141115
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor EfficacyDOI 10.1182/blood-2020-141115
Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapySemantic proximity
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editingSemantic proximity
Multiplex Cripsr/Cas9 Genome Editing to Generate Potent Universal CART and PD1-Deficient Cells Against LeukemiaSemantic proximity
Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome EditingSemantic proximity
CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapySemantic proximity
Boosting CAR-T cell therapy with CRISPR technologySemantic proximity
Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapySemantic proximity
The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune CellsSemantic proximity
A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapiesSemantic proximity
Applications and explorations of CRISPR/Cas9 in CAR T-cell therapySemantic proximity
CRISPR/Cas9: Role of genome editing in cancer immunotherapySemantic proximity
CAR-T Therapy and CRISPR/Cas9 in Cancer TreatmentSemantic proximity
Select a neighboring publication to make it the new centre.