Article
Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor
2019-12-03
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Purpose</h4> Rhabdoid tumor is a pediatric cancer characterized by the biallelic inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. SMARCB1 inactivation leads to SWI/SNF redistribution to favor a proliferative dedifferentiated cellular state. Although this deletion is the known oncogenic driver, SWI/SNF therapeutic targeting remains a challenge. <h4>Experimental...
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Identifiers and source
- Literature Corpus work
- 0222ed4c-e191-57dc-a7c1-01d44d9013fa
- DOI
- 10.1101/861484