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Atypical Teratoid Rhabdoid Tumour : From Tumours to Therapies

1 May 2018

Abstract excerpt

Atypical teratoid rhabdoid tumours (ATRTs) are the most common malignant central nervous system tumours in children 1 year of age and represent approximately 1-2% of all pediatric brain tumours. ATRT is a primarily monogenic disease characterized by the bi-allelic loss of the SMARCB1 gene, which encodes the hSNF5 subunit of the SWI/SNF chromatin remodeling complex. Though conventional dose chemotherapy is not...

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PMID: 29742888
DOI: 10.3340/jkns.2018.0061

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