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Article

Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.

Biomolecules - 27 Dec 2022

Yao Ning, Skiteva Olga, Chergui Karima

Abstract excerpt

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with late-onset Parkinson's disease (PD). Although PD affects men and women differently, longitudinal studies examining sex- and age-dependent alterations in mice carrying the G2019S mutation are limited. We examined if behavioral and neurochemical dysfunctions, as well as neurodegeneration, occur in male and female BAC...

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Identifiers

PMID: 36671436
DOI: 10.3390/biom13010051
PMCID: PMC9856037

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