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TGFβ and the Tumor Microenvironment in Colorectal Cancer

12 Apr 2023

Abstract excerpt

Growing evidence supports an important role of the tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC). Resident cells such as fibroblasts or immune cells infiltrating into the TME maintain continuous crosstalk with cancer cells and thereby regulate CRC progression. One of the most important molecules involved is the immunoregulatory cytokine transforming growth factor-β (TGFβ). TGFβ is...

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PMID: 37190048
DOI: 10.3390/cells12081139

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