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Crosstalk Between Sickle Cell Disease and Ferroptosis

13 Apr 2025

Abstract excerpt

Sickle cell disease (SCD) is an inherited hemoglobin disorder that is widespread across the globe. It is characterized by a very complex pathogenesis, but at the basis of the disease is the mutation of the HBB gene, which determines the production of a mutated hemoglobin: sickle cell hemoglobin (HbS). The polymerization of HbS, which occurs when the protein is in a deoxygenated state, and the greater fragility of...

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PMID: 40332185
DOI: 10.3390/ijms26083675

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