The paradox of HbSC disease-Not so benign after all.

Abstract excerpt

With the growing interest in precision medicine and personalized treatments for sickle cell disease (SCD) comes a realization that our approach to individuals living with the hemoglobin SC (HbSC) genotype is inadequate. For many decades HbSC was viewed as a milder form of SCD that does not demand aggressive management. Consequently, when resources, funding, and treatments for SCD were limited, clinical and...

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