Article

Loss-of-function of RNA-binding protein PRRC2B causes translational defects and cardiovascular malformation

2024-09-27

Abstract excerpt

Alternative splicing of pre-mRNA generates variant protein forms from a given gene, accounting for both functional redundancy and diversification. A novel RNA-binding protein, Pr o-rich C oiled- coil Containing Protein 2B (PRRC2B), has been shown to mediate both upstream (u)ORF- dependent and independent regulation of translation initiation, which is essential for cell cycle progression and proliferation. We id...

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Literature Corpus work: c04d8476-0744-5d36-9280-9a9ce57853ba
DOI: 10.1101/2024.09.26.24313895

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