Article
Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR.
Nucleic acids research - 6 Sept 2018
Phillips Brittany L, Banerjee Ayan, Sanchez Brenda J, Di Marco Sergio, Gallouzi Imed-Eddine, Pavlath Grace K, Corbett Anita H
Abstract excerpt
RNA processing is critical for proper spatial and temporal control of gene expression. The ubiquitous nuclear polyadenosine RNA binding protein, PABPN1, post-transcriptionally regulates multiple steps of gene expression. Mutations in the PABPN1 gene expanding an N-terminal alanine tract in the PABPN1 protein from 10 alanines to 11-18 alanines cause the muscle-specific disease oculopharyngeal muscular dystrophy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.