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Tumor-associated tissue-resident macrophages drive pancreatic cancer progression through IGF1-IGF1R signaling

2026-05-12

Abstract excerpt

<h4>Summary</h4> The specific contribution of tissue-resident macrophages (TRMs) to pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. Here, we found that a high abundance of TRM-derived tumor-associated macrophages (TRM-TAMs) is an independent indicator of poor prognosis in patients with PDAC. To elucidate the underlying mechanism, we established an advanced organoid platform (iMac-FPCO), which...

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Literature Corpus work
01dd4958-9fa2-54bb-9e61-78601208642d
DOI
10.64898/2026.05.08.723679
Open publication

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Tumor-associated tissue-resident macrophages drive pancreatic cancer progression through IGF1-IGF1R signalingDOI 10.64898/2026.05.08.723679
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