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Article

Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia.

Pharmacogenomics - 1 Feb 2021

Yuliwulandari Rika, Prayuni Kinasih, Razari Intan, Susilowati Retno W, Zulhamidah Yenni, Soedarsono Soedarsono, Sofro Abdul Salam M, Tokunaga Katsushi

Abstract excerpt

Background: Owing to the high resistance rate of tuberculosis (TB) to isoniazid, which is metabolized by N-acetyltransferase 2 (NAT2), we investigated the associations between NAT2 variants and multidrug-resistant (MDR)-TB. Materials & methods: The acetylator status based on NAT2 haplotypes of 128 patients with MDR-TB in Indonesia were compared with our published data from patients with anti-TB drug-induced liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33399479
DOI: 10.2217/pgs-2020-0163

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