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Article

BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes.

Thrombosis and haemostasis - 26 Jan 2017

Greenhalgh Katie A, Strachan Mark W, Alzahrani Saad, Baxter Paul D, Standeven Kristina F, Storey Robert F, Ariens Robert A S, Grant Peter J, Price Jackie F, Ajjan Ramzi A

Abstract excerpt

Both type 2 diabetes (T2DM) and Bβ448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BβArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BβArg448Lys on fibrin network characteristics in T2DM. Secondary...

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Identifiers

PMID: 27929198
DOI: 10.1160/TH16-07-0554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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