Mitochondrial Transplantation Promotes Protective Effector and Memory CD4 + T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4 + T cells

Abstract excerpt

Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), is a major global health concern, particularly affecting those with weakened immune systems, including the elderly. CD4 + T cell response is crucial for immunity against M.tb , but chronic infections and aging can lead to T cell exhaustion and senescence, worsening TB disease. Mitochondrial dysfunction, prevalent in aging and chronic...

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