Article
Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.
Cell metabolism - 8 Sept 2010
Nouws Jessica, Nijtmans Leo, Houten Sander M, van den Brand Mariël, Huynen Martijn, Venselaar Hanka, Hoefs Saskia, Gloerich Jolein, Kronick Jonathan, Hutchin Timothy, Willems Peter, Rodenburg Richard, Wanders Ronald, van den Heuvel Lambert, Smeitink Jan, Vogel Rutger O
Abstract excerpt
Acyl-CoA dehydrogenase 9 (ACAD9) is a recently identified member of the acyl-CoA dehydrogenase family. It closely resembles very long-chain acyl-CoA dehydrogenase (VLCAD), involved in mitochondrial beta oxidation of long-chain fatty acids. Contrary to its previously proposed involvement in fatty acid oxidation, we describe a role for ACAD9 in oxidative phosphorylation. ACAD9 binds complex I assembly factors...
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