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Systematic Approach Identifies Multiple Transcription Factor Perturbations That Rejuvenate Replicatively Aged Human Skin Fibroblasts

2022-11-20

Abstract excerpt

Rejuvenation, long a quixotic dream, recently became a possibility through exciting new approaches to counteract aging. For example, parabiosis and partial reprogramming through overexpressing four stem cell transcription factors (Yamanaka factors) both rejuvenate organisms and cells 1–5 . We hypothesize there are many other genetic solutions to human cell rejuvenation, and some solutions may be safer and more po...

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Literature Corpus work
524166dd-7500-5239-b26c-d520e664209c
DOI
10.1101/2022.11.20.517270
Open publication

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Systematic Approach Identifies Multiple Transcription Factor Perturbations That Rejuvenate Replicatively Aged Human Skin FibroblastsDOI 10.1101/2022.11.20.517270
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