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Article

TXNIP regulates peripheral glucose metabolism in humans.

PLoS medicine - 1 May 2007

Parikh Hemang, Carlsson Emma, Chutkow William A, Johansson Lovisa E, Storgaard Heidi, Poulsen Pernille, Saxena Richa, Ladd Christine, Schulze P Christian, Mazzini Michael J, Jensen Christine Bjørn, Krook Anna, Björnholm Marie, Tornqvist Hans, Zierath Juleen R, Ridderstråle Martin, Altshuler David, Lee Richard T, Vaag Allan, Groop Leif C, Mootha Vamsi K

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure. METHODS AND FINDINGS: We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling to identify...

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Source

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Identifiers

PMID: 17472435
DOI: 10.1371/journal.pmed.0040158
PMCID: PMC1858708

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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