Loss of m ¹ acp ³ Ψ ribosomal RNA modification is a major feature of cancer

Abstract excerpt

<h4>Summary</h4> The ribosome is an RNA-protein complex essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA). While mutations in ribosomal protein (RP) genes are known drivers of oncogenesis, oncogenic rRNA variants have remained elusive. We discovered a cancer-specific single nucleotide variation in 18S rRNA at nucleotide 1248.U in up to...

Topics

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• Cell Line, Transformed
• Cryoelectron Microscopy
• Dyskeratosis Congenita
• Peptidase Inhibition and Analysis
• Protein Biosynthesis
• Ribosomes
• RNA and protein synthesis mechanisms
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

01582608-f7c5-584f-8015-08bdc92b2e25

DOI

10.1101/840132