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Breaking Free: Development of Circular AAV Cargos for Targeted Seamless Integration in the Liver

2024-10-29

Abstract excerpt

<h4>Summary</h4> Recent advancements in gene insertion have shifted from DNA repair-dependent mechanisms to more precise approaches, enhancing safety and predictability for editing outcomes. Integrase-mediated programmable genomic integration (I-PGI) utilizes a DNA cargo to insert transgenes in a targeted, unidirectional manner. In vivo , where nuclear delivery of DNA is challenging, adeno-associated virus (AAV)...

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Literature Corpus work
01495647-d521-530c-8841-b92a70d481b3
DOI
10.1101/2024.10.26.620313
Open publication

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Breaking Free: Development of Circular AAV Cargos for Targeted Seamless Integration in the LiverDOI 10.1101/2024.10.26.620313
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