Genetic association of ErbB4 and human cortical GABA levels in vivo.

doi:10.1523/JNEUROSCI.1529-11.2011

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Article

Genetic association of ErbB4 and human cortical GABA levels in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2011

Marenco Stefano, Geramita Matthew, van der Veen Jan Willem, Barnett Alan S, Kolachana Bhaskar, Shen Jun, Weinberger Daniel R, Law Amanda J

Abstract excerpt

NRG1-ErbB4 signaling controls inhibitory circuit development in the mammalian cortex through ErbB4-dependent regulation of GABAergic interneuron connectivity. Common genetic variation in ErbB4 (rs7598440) has been associated with ErbB4 messenger RNA levels in the human cortex and risk for schizophrenia. Recent work demonstrates that Erbb4 is expressed exclusively on inhibitory interneurons, where its presence on...

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PMID: 21832192
DOI: 10.1523/JNEUROSCI.1529-11.2011
PMCID: PMC3159177

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NRG1

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