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Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

26 Apr 2017

Abstract excerpt

Many drugs designed to inhibit kinases have their clinical utility limited by cardiotoxicity-related label warnings or prescribing restrictions. While this liability is widely recognized, designing safer kinase inhibitors (KI) requires knowledge of the causative kinase(s). Efforts to unravel the kinases have encountered pharmacology with nearly prohibitive complexity. At therapeutically relevant concentrations,...

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PMID: 28453775
DOI: 10.1093/toxsci/kfx082

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