Article

Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for <i>LMNA</i> -related Cardiomyopathy

2026-06-16

Abstract excerpt

<h4>Objectives</h4> To define shared and variant-specific mechanisms underlying LMNA-associated dilated cardiomyopathy (DCM) and identify therapeutic candidates using human stem cell–based models. <h4>Background</h4> Variants in the gene LMNA, encoding lamin A/C, cause 5–10% of dilated cardiomyopathies (DCM) and are strongly associated with heart failure and arrhythmias. Yet, the mechanisms by which LMNA variant...

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Literature Corpus work: 56c02cb2-acbf-5b11-be7a-378fd883c543
DOI: 10.64898/2026.06.12.731852

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