Article

Immune gene co-expression networks are constrained by a non-linear topology spectral relationship

2025-12-28

Abstract excerpt

Inter-individual heterogeneity poses a fundamental challenge to systems-level characterization of immune states. When examined in isolation, network metrics exhibit extensive distributional overlap between conditions, providing little discriminatory power at the donor level. We hypothesized that immune states differ not in isolated properties but in the geometric constraints governing their joint distribution. We...

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Identifiers and source

Literature Corpus work: 010a6f4c-15d9-5492-a91e-1266485118bd
DOI: 10.64898/2025.12.25.696503

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