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Article

Multilayer modelling of the human transcriptome and biological mechanisms of complex diseases and traits.

NPJ systems biology and applications - 27 May 2021

Azevedo Tiago, Dimitri Giovanna Maria, Lió Pietro, Gamazon Eric R

Abstract excerpt

Here, we performed a comprehensive intra-tissue and inter-tissue multilayer network analysis of the human transcriptome. We generated an atlas of communities in gene co-expression networks in 49 tissues (GTEx v8), evaluated their tissue specificity, and investigated their methodological implications. UMAP embeddings of gene expression from the communities (representing nearly 18% of all genes) robustly identified...

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Identifiers

PMID: 34045472
DOI: 10.1038/s41540-021-00186-6
PMCID: PMC8160250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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