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Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS

7 Nov 2019

Abstract excerpt

Mitochondrial dysfunction is one of the converging paths for many neurodegenerative diseases, including ALS (amyotrophic lateral sclerosis), and TDP-43 pathology is the most common proteinopathy detected in ALS and ALS/FTLD (ALS/Frontotemporal lobar degeneration). We recently identified mitochondrial problems in corticospinal motor neurons (CSMN) and in Betz cells of patients with TDP-43 pathology. However, the...

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PMID: 31787882
DOI: 10.3389/fncel.2019.00489

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