Article

Cardiac-targeted PIASy Gene Silencing Mediates deSUMOylation of Caveolin-3 and Prevents Ischemia/reperfusion-induced Nav1.5 Down-regulation and Ventricular Arrhythmias

2021-12-30

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Abnormal myocardial expression and function of Nav1.5 causes lethal ventricular arrhythmias during myocardial ischemia-reperfusion (I/R). PIASy mediated Caveolin-3 (Cav-3) SUMO modification affects Cav-3 binding to ligand Nav1.5. PIASy activity is increased after myocardial I/R, whether or not this may be attributable to plasma membrane Na<...

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Literature Corpus work: 00ffe089-517c-5bf5-b97d-31318ad3c162
DOI: 10.21203/rs.3.rs-1163593/v1

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Cardiac-targeted PIASy Gene Silencing Mediates deSUMOylation of Caveolin-3 and Prevents Ischemia/reperfusion-induced Nav1.5 Down-regulation and Ventricular ArrhythmiasDOI 10.21203/rs.3.rs-1163593/v1Read

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