Article

Myocardial infarction creates a critical time window for AAV-based cardiac gene transfer

2024-11-05

Abstract excerpt

<title>Abstract</title> <p>Developing approaches to enhance adeno-associated virus (AAV)-based cardiac gene transfer is the key to successful cardiac gene therapy, but factors influencing AAV transduction remains poorly investigated. This study showed that myocardial infarction (MI) enhanced AAV transduction peaking at the third day post MI in mice. This excessive AAV enriched at the border zone potentially due t...

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Literature Corpus work: 909fbe32-7236-51e8-85c2-abff04935485
DOI: 10.21203/rs.3.rs-5291943/v1

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