Article
Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.
Circulation. Arrhythmia and electrophysiology - 1 Jan 2018
Vaidyanathan Ravi, Van Ert Hanora, Haq Kazi T, Morotti Stefano, Esch Samuel, McCune Elise C, Grandi Eleonora, Eckhardt Lee L
Abstract excerpt
BACKGROUND: In human cardiac ventricle, IK1 is mainly comprised Kir2.1, but Kir2.2 and Kir2.3 heterotetramers occur and modulate IK1. Long-QT syndrome-9-associated CAV3 mutations cause decreased Kir2.1 current density, but Kir2.x heterotetramers have not been studied. Here, we determine the effect of long-QT syndrome-9-CAV3 mutation F97C on Kir2.x homo- and heterotetramers and model-associated arrhythmia...
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