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Article

Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel

9 Nov 2018

Abstract excerpt

In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory protein for signaling molecules and compartmentalizes ion channels. Our lab has recently explored this sub-cellular microdomain and found that potassium inward rectifier Kir2.x is found in association with caveolin-3. The three cardiac Kir2.x isoforms (Kir2.1, Kir2.2, and Kir2.3) are the molecular correlate of IK1 in the...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 30473666
DOI: 10.3389/fphys.2018.01548

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