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Gβγ-GRK2 inhibition ameliorates synovitis and pathological macrophage activation in murine post-traumatic osteoarthritis

2022-03-31

Abstract excerpt

<h4>Background: </h4> and Purpose: The G protein-coupled receptor kinase 2 (GRK2) is an important regulator of inflammation and pathological macrophage phenotype in a variety of diseases. We hypothesize that Gβγ-GRK2 signaling promotes early inflammatory response and chondrocyte loss in osteoarthritis (OA). Experimental Approach: Using the destabilization of the medial meniscus (DMM) model in 12-week-old male C57B...

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Literature Corpus work
00e69782-cd0b-57cc-9f17-abb803cce400
DOI
10.22541/au.164873432.28611937/v1
Open publication

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Gβγ-GRK2 inhibition ameliorates synovitis and pathological macrophage activation in murine post-traumatic osteoarthritisDOI 10.22541/au.164873432.28611937/v1
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