Article

Computational validation of clonal and subclonal copy number alterations from bulk tumour sequencing

2021-02-13

Abstract excerpt

<h4> Abstract </h4> The identification of chromosome number alterations is now widespread in cancer research, but three features of genomic data hinder copy number calling and downstream analyses: the purity of the tumour sample, intra-tumour heterogeneity, and the ploidy of the tumour. To assess these features, consensus methods are often utilised, though these become onerous in projects that involve thousands...

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Literature Corpus work: 00d019ec-985b-5188-a643-75795a9ee5da
DOI: 10.1101/2021.02.13.429885

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