Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

15 May 2021

Abstract excerpt

The diagnosis of Parkinson's disease (PD) and atypical parkinsonian syndromes is difficult due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a synucleinopathy whose symptoms often overlap with PD. Exosomes isolated from blood by immunoprecipitation using CNS markers provide a window into the brain's biochemistry and may assist in distinguishing between PD and MSA. Thus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurological disorders and treatments
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33991233
DOI: 10.1007/s00401-021-02324-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophyPMID 33991233Read ↗

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunctionSemantic proximity Read ↗

Alpha-synuclein is increased in erythrocytes in Parkinson’s Disease casesSemantic proximity Read ↗

Parkinson’s disease biomarkers based on α‐synucleinSemantic proximity Read ↗

Alterations of Erythrocytic Phosphorylated Alpha-Synuclein in Different Subtypes and Stages of Parkinson's DiseaseSemantic proximity Read ↗

Analysis of α-Synuclein in Exosomes.Semantic proximity Read ↗

AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson’s disease diagnosisSemantic proximity Read ↗

α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasmaSemantic proximity Read ↗

Methods for detecting toxic α-synuclein species as a biomarker for Parkinson’s diseaseSemantic proximity Read ↗

Comparative analysis of total alpha-synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoformsSemantic proximity Read ↗

Multiple System Atrophy: Pathology, Pathogenesis, and Path ForwardSemantic proximity Read ↗

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s diseaseSemantic proximity Read ↗

Serum and Exosomal miR-7-1-5p and miR-223-3p as Possible Biomarkers for Parkinson’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.