AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson’s disease diagnosis

Abstract excerpt

Dear Editor, Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60 (El-Agnaf, 2003; Majbour, Vaikath et al., 2016). Motor symptoms, which is currently the major trait for PD diagnosis, appear when 50%–60% of dopaminergic neurons in the substantia nigra (SN) and 70%–80% of dopaminergic terminals in the striatum are lost...

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